کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5848521 | 1130190 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling Antitumor effects of a novel benzonaphthofurandione derivative (8e) on the human colon cancer cells in vitro and in vivo through cell cycle arrest accompanied with the modulation of EGFR and mTOR signaling](/preview/png/5848521.png)
چکیده انگلیسی
⺠Antitumor effects of a novel benzonaphthofurandione (8e) on colorectal cancer HCT 116 cells both in vitro and an in vivo. ⺠The anti-proliferative activity of 8e was associated with the induction of cell cycle arrest in the G0/G1 phase. ⺠The 8e-induced cell cycle arrest was well correlated with the suppression of CDK2, CDK4, cyclin D1, cyclin E, c-Myc, and pRb. ⺠The tumor growth in xenograft nude mice by 8e (10 mg/kg) significantly inhibited without any overt toxicity. ⺠The down-regulation of EGFR, Akt, and mTOR signalings were associated with the anti-proliferative activity of compound 8e.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 193, Issue 1, 15 August 2011, Pages 43-49
Journal: Chemico-Biological Interactions - Volume 193, Issue 1, 15 August 2011, Pages 43-49
نویسندگان
Hwa-Jin Chung, Hee-Kyung Rhee, Sang Kook Lee, Hea-Young Park Choo,