Nitric oxide donor, V-PROLI/NO, provides protection against arsenical induced toxicity in rat liver cells: Requirement for Cyp1a1

► V-PROLI/NO protects against the adverse effects of arsenic in rat liver cells. ► NO-releasing prodrug, V-PROLI/NO generates NO possibly via Cyp1a1 in rat liver cells. ► V-PROLI/NO reduces arsenic-induced toxicity and apoptosis. ► CYP450 required for NO production from V-PROLI/NO differs from rat and human.