کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5849152 | 1130706 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid
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کلمات کلیدی
GSHTBARSCGAPCPHO-1GPXGSTNQO1TBILALTCATDCFH-DAtetrachlorohydroquinoneTCHQCDNB1-chloro-2,4-dinitrobenzene - 1-کلرو-2،4-دینیتروبنزن2′,7′-dichlorodihydrofluorescein diacetate - 2 '، 7'-dichlorodihydrofluorescein diacetateROS - ROSAST - آسپارتات ترانس آمینازalanine transaminase - آلانین ترانس آمینازChlorogenic acid - اسید کلروژنیکTCBQ - بخش عمومی امور مالیaspartate transaminase - ترانس آمیناز آسپارتاتOxidative stress - تنش اکسیداتیوTUNEL - تونلSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکheme oxygenase 1 - همای اکسیژناز 1Pentachlorophenol - پنتا کلروفنلCatalase - کاتالازtotal bilirubin - کل بیلی روبینGlutathione - گلوتاتیونglutathione-S-transferase - گلوتاتیون S-ترانسفرازglutathione reductase - گلوتاتیون ردوکتازglutathione peroxidase - گلوتاتیون پراکسیدازReactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid Tetrachlorobenzoquinone induces acute liver injury, up-regulates HO-1 and NQO1 expression in mice model: The protective role of chlorogenic acid](/preview/png/5849152.png)
چکیده انگلیسی
Tetrachlorobenzoquinone (TCBQ) is an active metabolite of pentachlorophenol (PCP). Although PCP has been investigated extensively, there are only a few reports describing the toxicity effect of TCBQ, and no report regarding TCBQ-induced liver injury in vivo. In the current study, we aimed to examine the acute hepatic toxicity of TCBQ in the mice model. Chlorogenic acid (CGA) exhibits promising antioxidant activity in the past studies, thus, the second aim of this study was to evaluate the protective effect of CGA on TCBQ-induced liver injury. Our results indicated TCBQ-intoxication caused marked liver cell necrosis and inflammation but not apoptosis, and this damage was alleviated by CGA treatment. Meantime, TCBQ-intoxication enhanced serum ALT, AST activities, TBIL content, hepatic oxidative stress and lipid peroxidation, decreased GSH content and inhibited the activities of antioxidant enzymes. Western blot and immunohistochemical analysis showed that TCBQ marked up-regulated HO-1 and NQO1 expression. On the other hand, pretreatment of CGA reduced TCBQ-induced liver damage remarkably. Taking together, these results revealed that TCBQ has strong hepatic toxic effect, and at least a part of this effect is initiated by free radical and relieved with CGA administration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Toxicology and Pharmacology - Volume 37, Issue 3, May 2014, Pages 1212-1220
Journal: Environmental Toxicology and Pharmacology - Volume 37, Issue 3, May 2014, Pages 1212-1220
نویسندگان
Demei Xu, Lihua Hu, Xiaomin Xia, Jianbo Song, Lingrui Li, Erqun Song, Yang Song,