Effect of protein malnutrition on the metabolism and toxicity of cisplatin, 5-fluorouracil and mitomycin C in rat stomach

► Low-protein intake worsens cisplatin, 5-fluorouracil and mitomycin C gastrotoxicity. ► Protein malnutrition enhances metabolic activation of cisplatin in rat stomach. ► Malnutrition enhances cysteine conjugate β-lyase-mediated metabolism of cisplatin. ► Protein malnutrition reduces the elimination of 5-fluorouracil in rat stomach. ► Protein malnutrition enhances 2-electron reduction of mitomycin C in rat stomach.