کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5851691 | 1561786 | 2013 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Protective effects of naringin against paraquat-induced acute lung injury and pulmonary fibrosis in mice
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کلمات کلیدی
i.g.i.p.BCAMMP-9BALHO-1NACCATHYPTIMP-1MDATGF-βNF-κBGSH-Px - GSH-PXH&E - H & EAcute lung injury - آسیب ریه حادAntioxidant - آنتی اکسیدانAli - اماbicinchoninic acid - بیسینکنینیک اسیدtransforming growth factor-β - تبدیل فاکتور رشد βtumor necrosis factor-α - تومور نکروز عامل αIntraperitoneally - داخل صفاقیintragastric - داخل معدهSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازAnti-inflammatory - ضدالتهابTNF-α - فاکتور نکروز توموری آلفاnuclear factor kappa B - فاکتور هسته ای کاپا BPulmonary fibrosis - فیبروز ریهbronchoalveolar lavage - لارو برونکلو آلوئولارMatrix metalloproteinase-9 - ماتریکس متالوپروتئیناز -9malonaldehyde - مالونالدئیدNaringin - نارانینگینN-acetyl cysteine - نیتستیل سیستئینHematoxylin and Eosin - هماتوکسیلین و ائوزینheme oxygenase - همگام اکسژنازhydroxyproline - هیدروکسی پرولینParaquat - پاراکواتCatalase - کاتالازglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present study evaluates protective effects of naringin against paraquat (PQ)-induced acute lung injury (ALI) and pulmonary fibrosis in mice. Survival probability against PQ intoxication was tested by a single intraperitoneal injection of PQ. Results showed that survival rates of mice exposed to PQ only (50 mg/kg within 7 days) were much lower than that in mice daily treatment with NAC or naringin. Moreover, protection against PQ-induced ALI was tested by daily pretreatment mice with saline, NAC or naringin for 3 days before PQ (30 mg/kg, i.p.). Results showed that increase in leukocytes infiltration and overexpressions of TNF-α and TGF-β1 caused by 8 h of PQ exposure were dose-dependently ameliorated by naringin. Furthermore, protection against PQ-induced pulmonary fibrosis was tested by pretreatment mice with PQ (20 mg/kg, i.p.), and then daily administration with saline, NAC or naringin for prolonged 21 days. Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-α, TGF-β1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1. These results indicated that naringin had effective protection against PQ-induced ALI and pulmonary fibrosis.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 133-140
Journal: Food and Chemical Toxicology - Volume 58, August 2013, Pages 133-140
نویسندگان
Yan Chen, Yi-chu Nie, Yu-long Luo, Feng Lin, Yan-fang Zheng, Guo-hua Cheng, Hao Wu, Ke-jian Zhang, Wei-wei Su, Jian-gang Shen, Pei-bo Li,