کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856053 1562124 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Trichloroethylene exposure aggravates behavioral abnormalities in mice that are deficient in superoxide dismutase
ترجمه فارسی عنوان
قرار گرفتن در معرض تری کلرولییدل باعث اختلالات رفتاری در موش هایی که در سوپر اکسید دیسموتاز کمبود دارند
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


- Trichloroethylene (TCE) aggravates motor behavior in SOD1-deficient mice.
- TCE results in a decrease in SOD1 protein production in cultured neuroblastoma cells.
- The toxic effects of TCE were enhanced in cells with inhibited SOD1 activity.

Trichloroethylene (TCE) has been implicated as a causative agent for Parkinson's disease (PD). The administration of TCE to rodents induces neurotoxicity associated with dopaminergic neuron death, and evidence suggests that oxidative stress as a major player in the progression of PD. Here we report on TCE-induced behavioral abnormality in mice that are deficient in superoxide dismutase 1 (SOD1). Wild-type (WT) and SOD1-deficient (Sod1−/−) mice were intraperitoneally administered TCE (500 mg/kg) over a period of 4 weeks. Although the TCE-administrated Sod1−/− mice showed marked abnormal motor behavior, no significant differences were observed among the experimental groups by biochemical and histopathological analyses. However, treating mouse neuroblastoma-derived NB2a cells with TCE resulted in the down regulation of the SOD1 protein and elevated oxidative stress under conditions where SOD1 production was suppressed. Taken together, these data indicate that SOD1 plays a pivotal role in protecting motor neuron function against TCE toxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 79, August 2016, Pages 83-90
نویسندگان
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