کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5856405 1562127 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Tobacco-specific N-nitrosamines NNN and NNK levels in cigarette brands between 2000 and 2014
چکیده انگلیسی


- Tobacco specific nitrosamines, NNN and NNK, in cigarette smoke and tobacco filler across 2000 to 2014 were investigated.
- The data indicate a substantial reduction of both NNN and NNK in tobacco filler and cigarette smoke.
- Downward trend observed on NNN and NNK levels overlap with measures taken to reduce TSNA formation in tobacco.

The evolution of the levels of tobacco-specific N-nitrosamines (TSNA), N-nitrosonornicotine (NNN) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream (MS) cigarette smoke is investigated based on smoke and tobacco chemistry data of cigarette brands sold by Philip Morris International (PMI) between 2000 and 2014. A total of 315 cigarette samples representing a wide range of product and design characteristics manufactured by PMI between 2008 and 2014 were analyzed and compared to a previously published dataset of PMI brands manufactured in 2000. The data indicate that there is a substantial reduction of NNN and NNK levels in tobacco fillers and MS cigarette smoke per mg of tar and per mg of nicotine using Health Canada Intense (HCI) machine-smoking regime. This observed reduction in NNN and NNK levels in MS cigarette smoke is also supported by the downward trend observed on NNN and NNK levels in USA flue-cured Virginia and Burley tobacco lots from 2000 to 2014 crops, reflecting effectiveness of measures taken on curing and agricultural practices designed to minimize TSNA formation in tobacco.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 76, April 2016, Pages 113-120
نویسندگان
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