کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5856574 | 1131978 | 2015 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBaseâ¢
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کلمات کلیدی
Concomitant medicationsICSRCOXAERSThree-dimensionalTNFFDAMedDRANSAIDEBGMOTCBSEPADEAPAPDrug-induced liver injury - آسیب کبدی ناشی از مواد مخدرAngiotensin II receptor antagonist - آنتاگونیست گیرنده آنژیوتانسین IIcyclooxygenase - آنزیم سیکلواکسیژنازAngiotensin converting enzyme inhibitor - آنژیوتانسین تبدیل آنزیم مهار کنندهAcetaminophen - استامینوفن over the counter - بیش از ضدAdverse drug events - حوادث مربوط به داروهای جانبیtwo-dimensional - دو بعدیDILI - دیلیWorld Health Organization - سازمان بهداشت جهانیFood and Drug Administration - سازمان غذا و داروHepatotoxicity - سمیت کبدAdverse Event Reporting System - سیستم گزارش رویداد نادرستAnatomical Therapeutic Chemical Classification - طبقه بندی شیمی درمانی آناتومیکیNon-steroidal anti-inflammatory drug - غیر استروئیدی دارو ضد التهابیtumor necrosis factor - فاکتور نکروز تومورSelective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابیACEI یا angiotensin convert enzyme inhibitor - مهارکننده آنزیم تبدیلکننده آنژیوتانسینSSRI - مهارکنندههای بازجذب سروتونینDrug induced liver injury - مواد مخدر آسیب کبدی را ایجاد می کندBile salt export pump - پمپ صادرات نمک صفرWHO - که
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBase⢠Comedications alter drug-induced liver injury reporting frequency: Data mining in the WHO VigiBaseâ¢](/preview/png/5856574.png)
چکیده انگلیسی
Polypharmacy is common, and may modify mechanisms of drug-induced liver injury. We examined the effect of these drug-drug interactions on liver safety reports of four drugs highly associated with hepatotoxicity. In the WHO VigiBaseâ¢, liver event reports were examined for acetaminophen, isoniazid, valproic acid, and amoxicillin/clavulanic acid. Then, we evaluated the liver event reporting frequency of these 4 drugs in the presence of co-reported medications. Each of the 4 primary drugs was reported as having more than 2000 liver events, and co-reported with more than 600 different medications. Overall, the effect of 2275 co-reported drugs (316 drug classes) on the reporting frequency was analyzed. Decreased liver event reporting frequency was associated with 245 drugs/122 drug classes, including anti-TNFα, opioids, and folic acid. Increased liver event reporting frequency was associated with 170 drugs/82 drug classes; in particular, halogenated hydrocarbons, carboxamides, and bile acid sequestrants. After adjusting for age, gender, and other co-reported drug classes, multiple co-reported drug classes were significantly associated with decreased/increased liver event reporting frequency in a drug-specific/unspecific manner. In conclusion, co-reported medications were associated with changes in the liver event reporting frequency of drugs commonly associated with hepatotoxicity, suggesting that comedications may modify drug hepatic safety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 72, Issue 3, August 2015, Pages 481-490
Journal: Regulatory Toxicology and Pharmacology - Volume 72, Issue 3, August 2015, Pages 481-490
نویسندگان
Ayako Suzuki, Nancy A. Yuen, Katarina Ilic, Richard T. Miller, Melinda J. Reese, H. Roger Brown, Jeffrey I. Ambroso, J. Gregory Falls, Christine M. Hunt,