A study to evaluate the effect on Mouth Level Exposure and biomarkers of exposure estimates of cigarette smoke exposure following a forced switch to a lower ISO tar yield cigarette

► Cigarette smokers recruited into a clinical study in Germany. ► Smoke constituent exposure estimated using two methods; filter analysis and biomarkers. ► Smokers switched to lower ISO tar yield cigarettes and estimates repeated. ► Switching to lower yield cigarette resulted in reductions in exposure estimates. ► Good correlation between both exposure estimates, maintained after switching.