Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen

► We evaluated the weight of evidence for methanol carcinogenesis in humans. ► Our Hypothesis-Based Weight-of-Evidence approach is applied to study quality issues. ► Bioassays and mode of action were interpreted with a hypothesis-based approach. ► We weighed consistency and plausibility of inferential logic about human risk. ► We considered alternative explanations for outcomes of questioned studies.