کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5857732 | 1132028 | 2011 | 10 صفحه PDF | دانلود رایگان |

To investigate the chronic toxicity of cyadox, a growth promoting agent, five groups of Wistar rats (30 rats/group/sex) were fed with the diets containing cyadox (0, 100, 400 and 2000Â mg/kg) or olaquindox (400Â mg/kg) for 78Â weeks. There were significant decreases in body weights in both genders during most of the study period in 2000Â mg/kg cyadox and 400Â mg/kg olaquindox rats. Significant decreases in serum alkaline aminotransferase in the 2000Â mg/kg cyadox rats at weeks 26, 52 and 78 were observed. Relative weights of liver and kidney were significantly increased in 2000Â mg/kg cyadox and 400Â mg/kg olaquindox rats at weeks 26, 52 and 78. A significant increase in relative brain and heart weights in 2000Â mg/kg cyadox males was observed. The histopathological examinations revealed that 2000Â mg/kg cyadox diet or 400Â mg/kg olaquindox diet could induce proliferation of bile canaliculi in the portal area of liver and swelling and fatty degeneration of the proximal renal tubular epithelial cells in kidneys. In conclusion, the target organs of cyadox for rats were liver and kidney. The no-observed-adverse-effect level of cyadox in this study was estimated to be 400Â mg/kg diet.
Journal: Regulatory Toxicology and Pharmacology - Volume 59, Issue 2, March 2011, Pages 324-333