HSP90 inhibition induces cytotoxicity via down-regulation of Rad51 expression and DNA repair capacity in non-small cell lung cancer cells

► HSP90 inhibition by 17-AAG decreases cellular Rad51 expression. ► 17-AAG downregulates the DNA repair capacity of human lung cancer cells. ► Rad51 plays a protective role in 17-AAG-induced cytotoxicity.