کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5858418 | 1562165 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluating chemical effects on mammary gland development: A critical need in disease prevention
ترجمه فارسی عنوان
بررسی تاثیرات شیمیایی بر توسعه ی پستان: نیاز اساسی در پیشگیری از بیماری است
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کلمات کلیدی
غده پستانی، توسعه، سرطان پستان، ترکیبات غشایی مصنوعی، تست سمیت،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Although understanding the environmental factors that contribute to breast cancer could improve disease prevention, standard chemical testing protocols do not adequately evaluate chemicals' effects on breast development. Evidence suggests: (1) mammary gland (MG) development is a complex process that extends from gestation through fetal and neonatal growth, puberty, and pregnancy; (2) altered MG development can increase the risk of breast cancer and other adverse outcomes; and (3) chemical exposures during susceptible windows of development may alter the MG in ways that increase risk for later disease. Together, these highlight the need to better understand the complex relationship between exposure to endocrine disrupting compounds (EDCs) and the alterations in MG morphology and gene expression that ultimately increase disease risk. Changing guideline toxicity testing studies to incorporate perinatal exposures and MG whole mounts would generate critical knowledge about the effects of EDCs on the MG and could ultimately inform disease prevention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 54, July 2015, Pages 148-155
Journal: Reproductive Toxicology - Volume 54, July 2015, Pages 148-155
نویسندگان
Gwendolyn Osborne, Ruthann Rudel, Megan Schwarzman,