کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5858877 | 1562173 | 2014 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Acute testicular toxicity induced by melamine alone or a mixture of melamine and cyanuric acid in mice
ترجمه فارسی عنوان
مسمومیت بیضه حاد ناشی از ملامین به تنهایی یا مخلوطی از ملامین و اسید سیانوریک در موش
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی
Eight-week-old male Kunming mice were administered either melamine (MA, 30, 140, or 700Â mg/kg/day), a melamine and cyanuric acid mixture (MC, each at 15, 70, or 350Â mg/kg/day), or vehicle (control) for 3 consecutive days. Testicular toxicity was evaluated on days 1 and 5 after the final exposure. The testicular and epididymal weights and serum testosterone level were significantly decreased in the highest MC group (350Â mg/kg/day). Histopathologically, both MA and MC caused obvious lesions in the testis and epididymis, with significant increases in sperm abnormalities. By TEM, the blood-testis barrier was damaged dose dependently. TUNEL staining showed that both MA and MC induced increases in germ cell apoptosis. The Sertoli cell vimentin was collapsed in the treated animals as detected by immunohistochemical staining and Western blotting. This study demonstrated that both MA and MC treatments could disrupt the blood-testis barrier and cause a clear testicular toxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 46, July 2014, Pages 1-11
Journal: Reproductive Toxicology - Volume 46, July 2014, Pages 1-11
نویسندگان
Lingling Chang, Ruiping She, Longhuan Ma, Hua You, Fengjiao Hu, Tongtong Wang, Xiao Ding, Zhaojie Guo, Majid Hussain Soomro,