کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5859794 | 1562616 | 2016 | 27 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin](/preview/png/5859794.png)
چکیده انگلیسی
At the receptor level, 0.001-10 μM BEA or FB1 did not induce any agonist responses in the RGAs. However at non-cytotoxic concentrations, an antagonistic effect was exhibited by FB1 on the androgen nuclear receptor transcriptional activity at 10 μM and BEA on the progestagen and glucocorticoid receptors at 1 μM. MTT analysis showed no decrease in cell viability at any concentration of FB1, whereas BEA showed a significant decrease in viability at 10 μM. HCA analysis confirmed that the reduction in the progestagen receptor transcriptional activity at 1 μM BEA was not due to pre-lethal toxicity. In addition, BEA (10 μM) induced significant toxicity in both the TM-Luc (progestagen responsive) and Caco-2 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 257, 22 August 2016, Pages 1-10
Journal: Toxicology Letters - Volume 257, 22 August 2016, Pages 1-10
نویسندگان
Celia Fernández-Blanco, Caroline Frizzell, Maeve Shannon, Maria-Jose Ruiz, Lisa Connolly,