JNK and p38 MAPK regulate oxidative stress and the inflammatory response in chlorpyrifos-induced apoptosis

► Chlorpyrifos induces apoptotic cell death in SH-SY5Y cells. ► ROS involved in chlorpyrifos-induced apoptotic cell death. ► MAPKs signaling pathways are required for chlorpyrifos-induced apoptosis. ► Chlorpyrifos up-regulates COX-2 expression. ► COX-2 is activated by JNK and p38 MAPKs signaling pathways.