The dynamics of accumulation of PCBs in cultured adipocytes vary with the cell lipid content and the lipophilicity of the congener

► Accumulated amounts of PCBs in cells differ according to the in vitro model. ► Accumulated levels of PCBs were strongly correlated with lipid levels in cells. ► Dynamics of accumulation importantly differed according to the PCB congener. ► The log P was a major parameter governing PCB dynamics across the plasma membrane.