Toxicity evaluation of individual and mixed enniatins using an in vitro method with CHO-K1 cells

► Individual enniatins A, A1, B and B1 are implicated in cytotoxicity effects. ► Enniatins combinations increase toxicological effects on CHO-K1 cells. ► Synergistic effect was observed in ENs A + A1, ENs A + B, ENs A1 + B1, ENs A + A1 + B and ENs A + B + B1 mixtures. ► Tertiary ENs A + A1 + B1 and ENs A1 + B + B1 combinations showed antagonistic effect.