Induction of apoptosis in human ovarian cancer cells by new anticancer compounds, epothilone A and B

► Antiproliferative capacity of Epo A and B in SKOV-3 cells in comparison to PTX were studied. ► Epothilones are more cytotoxic than PTX and generate apoptosis mediated by ROS. ► Phosphatidylserine externalization and decrease in membrane potential were observed. ► Chromatin condensation and apoptotic bodies were noted.