Attenuated effect of tungsten carbide nanoparticles on voltage-gated sodium current of hippocampal CA1 pyramidal neurons

► This study investigated the neuro-safety of tungsten carbide nanoparticles (nano-WC). ► The effect of nano-WC on CA1 neurons was investigated using patch-clamp technique. ► Results showed that nano-WC can decrease amplitudes of INa and action potential. ► That effect might be one of initial signs of neurotoxicity caused by nano-WC.