Sulforaphane induces cytotoxicity and lysosome- and mitochondria-dependent cell death in colon cancer cells with deleted p53

► Sulforaphane (SF) is cytotoxic in colon cancer cells HCT-116 p53KO. ► Sulforaphane induces mitochondrial caspase-dependent apoptosis. ► SF activates JNK and induces lysosomal membrane permeabilization. ► SF induces changes in the expression of Bax and Bcl and activates Bid.