کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5900655 1568826 2015 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transsynaptic trophic effects of steroid hormones in an avian model of adult brain plasticity
ترجمه فارسی عنوان
اثرات ترسی سیناپتیک هورمونهای استروئیدی در یک مدل پرندگان از پلاستیک بالغ مغز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


- Adult avian song control system shows pronounced seasonal plasticity.
- Plasticity is regulated by testosterone (T) and its androgenic and estrogenic metabolites.
- T can act directly on neurons or transsynaptically by steroid interactions with neurotrophins.
- Transsynaptic trophic effects can be anterograde or retrograde.

The avian song control system provides an excellent model for studying transsynaptic trophic effects of steroid sex hormones. Seasonal changes in systemic testosterone (T) and its metabolites regulate plasticity of this system. Steroids interact with the neurotrophin brain-derived neurotrophic factor (BDNF) to influence cellular processes of plasticity in nucleus HVC of adult birds, including the addition of newborn neurons. This interaction may also occur transsynpatically; T increases the synthesis of BDNF in HVC, and BDNF protein is then released by HVC neurons on to postsynaptic cells in nucleus RA where it has trophic effects on activity and morphology. Androgen action on RA neurons increases their activity and this has a retrograde trophic effect on the addition of new neurons to HVC. The functional linkage of sex steroids to BDNF may be of adaptive value in regulating the trophic effects of the neurotrophin and coordinating circuit function in reproductively relevant contexts.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Frontiers in Neuroendocrinology - Volume 37, April 2015, Pages 119-128
نویسندگان
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