کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5903670 | 1157102 | 2012 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: A biochemical and histopathological evaluation
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کلمات کلیدی
GPXUNXStatistical Package for the Social ScienceDOCASPSSTBARSDMFGSHTCADNPHTBADMRTHClH&E - H & EDuncan’s multiple range test - آزمون چند دامنه دانکنTrichloro acetic acid - اسید استیک تریکلروThiobarbituric acid - اسید تیوباربیتوریکhydrochloric acid - اسید هیدروکلریک یا اسید کلریدریک یا جوهر نمک Cardiovascular diseases - بیماری قلبی-عروقی deoxycorticosterone acetate - دئوسکوکورتیکوسترون استاتdimethyl formamide - دی متیل فرمامیدconjugated dienes - دین های کنجوج شدهdinitrophenylhydrazine - دینیتروفنیل هیدرازینCVD - رسوب دهی شیمیایی بخار World Health Organisation - سازمان بهداشت جهانیSOD - سدSuperoxide dismutase - سوکسوکس دیسموتازLOOH - لئوthiobarbituric acid reactive substances - مواد واکنش پذیر اسید تیوباربیتوریکNADH - نادانNitric oxide - نیتریک اکسیدNAD, nicotinamide adenine dinucleotide - نیکوتینامید آدنین دینوکلئوتیدhaematoxylin and eosin - هماتوکسیلین و ائوزینlipid hydroperoxides - هیدروپراکسید لیپیدreduced glutathione - کاهش گلوتاتیونWHO - کهglutathione peroxidase - گلوتاتیون پراکسیداز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: A biochemical and histopathological evaluation Morin attenuates blood pressure and oxidative stress in deoxycorticosterone acetate-salt hypertensive rats: A biochemical and histopathological evaluation](/preview/png/5903670.png)
چکیده انگلیسی
The present study was designed to evaluate the antihypertensive and antioxidant effect of morin, a flavonoid against deoxycorticosterone acetate (DOCA)-salt induced hypertension in male Wistar rats. Hypertension was induced in uninephrectomized rats (UNX) by weekly twice subcutaneous injection of DOCA (25Â mg/kg) and 1% NaCl in the drinking water for six consecutive weeks. The DOCA-salt hypertensive rats showed significant (P < .05) increase in the systolic and diastolic blood pressure, heart rate, water intake and organ weights (kidney, heart, aorta and liver). DOCA-salt hypertensive rats also showed significant (P < .05) increase in the levels of thiobarbituric acid reactive substances, lipid hydroperoxides and conjugated dienes in plasma and tissues (kidney, heart, aorta and liver), and significant (P < .05) decrease in the body weight, nitrite and nitrate levels in plasma and heart. Furthermore, the activities of enzymic antioxidants such as superoxide dismutase, catalase and glutathione peroxidase in erythrocyte and tissues and the levels of non-enzymic antioxidants such as reduced glutathione, vitamin C and vitamin E in plasma and tissues were significantly (P < .05) decreased in DOCA-salt rats. Morin supplementation (50Â mg/kg) daily for six weeks brought back all the above parameters to near normal level. The above findings were confirmed by the histopathological examination. No significant (P < .05) effect was observed in UNX-rats treated with morin (50Â mg/kg). These results suggest that morin acts as an antihypertensive and antioxidant agent against DOCA-salt induced hypertension.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 61, Issue 8, August 2012, Pages 1087-1099
Journal: Metabolism - Volume 61, Issue 8, August 2012, Pages 1087-1099
نویسندگان
Pichavaram Prahalathan, Subramanian Kumar, Boobalan Raja,