کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5905635 | 1159922 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Association of single nucleotide polymorphisms of ERCC1 and XPF with colorectal cancer risk and interaction with tobacco use
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کلمات کلیدی
SPSSXPFERCC3ERCC2HWEmiRNAsDNA - DNA یا اسید دزوکسی ریبونوکلئیکNER - DOWNdeoxyribonucleic acid - اسید deoxyribonucleicStatistical Package for Social Science - بسته های آماری برای علوم اجتماعیexcision repair cross-complementation group 1 - ترمیم مجدد مکمل گروه 1Hardy–Weinberg equilibrium - تعادل هاردی-وینبرگRisk - خطرmicroRNAs - ریز آرانایColorectal cancer - سرطان روده بزرگconfidence interval - فاصله اطمینانodds ratio - نسبت شانس هاpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمرازGenetic polymorphisms - پلیمورفیسم ژنتیکیSingle nucleotide polymorphism - پلیمورفیسم تک نوکلئوتیدیSNP - چندریختی تک-نوکلئوتیدERCC1 - ژن ERCC1
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigated the association between polymorphisms in excision repair cross-complementation group 1 (ERCC1) (rs3212986, rs2298881 and rs11615) and xeroderma pigmentosum-complementation group F (XPF) (rs2276466 and rs6498486) and risk of colorectal cancer. A 1:1 matched case-control study was conducted. Conditional regression analysis indicated that individuals carrying the ERCC1 rs3212986 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with subjects with the GG genotype. Similarly, subjects carrying the rs11615 TT genotype and T allele had a marginally increased risk of colorectal cancer when compared with those with the CC genotype. Stratified analysis revealed that individuals with rs3212986 TT who were current or former smokers had a significantly increased risk of colorectal cancer, and a significant interaction was found between this SNP and cigarette smoking. In conclusion, our study suggests that rs3212986 and rs11615 polymorphisms are associated with risk of colorectal cancer in a Chinese population, particularly in smokers. This finding could be useful in revealing the genetic characteristics of colorectal cancer, and suggests more effective strategies for prevention and treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gene - Volume 548, Issue 1, 10 September 2014, Pages 1-5
Journal: Gene - Volume 548, Issue 1, 10 September 2014, Pages 1-5
نویسندگان
Ruizhi Hou, Yan Liu, Ye Feng, Libo Sun, Zhenbo Shu, Jisheng Zhao, Shujuan Yang,