کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5907880 | 1160880 | 2014 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Characterization of the peripheral blood transcriptome in a repeated measures design using a panel of healthy individuals
ترجمه فارسی عنوان
مشخص نمودن ترانسکتوموم خون محیطی در یک اندازه گیری تکراری با استفاده از یک پنل افراد سالم
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کلمات کلیدی
خون، ترانسکتیکوم تغییر بیان ژن، سیستم ایمنی، بیومونیتوری، سلامت عمومی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
ژنتیک
چکیده انگلیسی
A repeated measures microarray design with 22 healthy, non-smoking volunteers (aging 32 ± 5 years) was set up to study transcriptome profiles in whole blood samples. The results indicate that repeatable data can be obtained with high within-subject correlation. Probes that could discriminate between individuals are associated with immune and inflammatory functions. When investigating possible time trends in the microarray data, we have found no differential expression within a sampling period (within-season effect). Differential expression was observed between sampling seasons and the data suggest a weak response of genes related to immune system functioning. Finally, a high number of probes showed significant season-specific expression variability within subjects. Expression variability increased in springtime and there was an association of the probe list with immune system functioning. Our study suggests that the blood transcriptome of healthy individuals is reproducible over a time period of several months.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 103, Issue 1, January 2014, Pages 31-39
Journal: Genomics - Volume 103, Issue 1, January 2014, Pages 31-39
نویسندگان
Patrick De Boever, Britt Wens, Anyiawung Chiara Forcheh, Hans Reynders, Vera Nelen, Jos Kleinjans, Nicolas Van Larebeke, Geert Verbeke, Dirk Valkenborg, Greet Schoeters,