کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5907940 1160893 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pathway-based genetic analysis of preterm birth
ترجمه فارسی عنوان
تجزیه و تحلیل ژنتیکی مبتنی بر مسیر زایمان زودرس
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
چکیده انگلیسی

Preterm birth in the United States is now 12%. Multiple genes, gene networks, and variants have been associated with this disease. Using a custom database for preterm birth (dbPTB) with a refined set of genes extensively curated from literature and biological databases, we analyzed GWAS of preterm birth for complete genotype data on nearly 2000 preterm and term mothers. We used both the curated genes and a genome-wide approach to carry out a pathway-based analysis. There were 19 significant pathways, which withstood FDR correction for multiple testing that were identified using both the curated genes and the genome-wide approach. The analysis based on the curated genes was more significant than genome-wide in 15 out of 19 pathways. This approach demonstrates the use of a validated set of genes, in the analysis of otherwise unsuccessful GWAS data, to identify gene-gene interactions in a way that enhances statistical power and discovery.

► We use both the curated genes and a genome-wide approach for pathway analysis. ► The analysis based on the curated genes was more significant than genome-wide. ► We identify gene-gene interactions that enhance statistical power and discovery. ► We report significant pathway-based associations for preterm birth. ► The results suggest several, important mechanistic implications for preterm birth.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Genomics - Volume 101, Issue 3, March 2013, Pages 163-170
نویسندگان
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