RCM: A novel association approach to search for coronary artery disease genetic related metabolites based on SNPs and metabolic network

► We proposed a genetic-based approach to identify CAD genetic risk compounds (SGRCs). ► Most SGRCs concentrated on mitochondria, endoplasmic reticulum and peroxisome. ► We adopted literature retrieval to validate our results. ► We established a comprehensive CAD-causing reference table for SGRCs. ► SGRCs were discovered to be strongly associated with lipid metabolism in CAD.