کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5913062 1161860 2014 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanisms of genome instability induced by RNA-processing defects
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی ژنتیک
پیش نمایش صفحه اول مقاله
Mechanisms of genome instability induced by RNA-processing defects
چکیده انگلیسی
The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here, we discuss how RNA-processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Genetics - Volume 30, Issue 6, June 2014, Pages 245-253
نویسندگان
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