کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5913224 1162173 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Histone Acetylation Enzymes Coordinate Metabolism and Gene Expression
ترجمه فارسی عنوان
آنزیم استیل شدن هیستون متابولیسم هماهنگ و بیان ژن
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش گیاه شناسی
چکیده انگلیسی
Histone lysine acetylation is well known for being important in the epigenetic regulation of gene expression in eukaryotic cells. Recent studies have uncovered a plethora of acetylated proteins involved in important metabolic pathways, such as photosynthesis and respiration in plants. Enzymes involved in histone acetylation and deacetylation are being identified as regulators of acetylation of metabolic enzymes. Importantly, key metabolites, such as acetyl-CoA and NAD+, are involved in protein acetylation and deacetylation processes, and their cellular levels may regulate the activity of histone acetyltransferases (HAT) and deacetylases (HDAC). Further research is required to determine whether and how HATs and HDACs sense cellular metabolite signals to control gene expression and metabolic enzyme activity through lysine acetylation and deacetylation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Trends in Plant Science - Volume 20, Issue 10, October 2015, Pages 614-621
نویسندگان
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