Effects of process parameters on the colloidal properties of polycaprolactone microparticles prepared by double emulsion like process

In the first step, inner aqueous phase (W1) was added to dichloromethane (DCM) containing polycaprolactone (PCL) polymer and homogenized to form primary emulsion (W1/O). In the second step, the primary emulsion was emulsified in the outer aqueous phase (W2) containing polyvinyl alcohol (PVA) as stabilizer using ultra-turrax to have double emulsion (W1/O/W2). SEM microgram shows the particles morphology.