Pomegranate phytosterol (β-sitosterol) and polyphenolic antioxidant (punicalagin) addition to statin, significantly protected against macrophage foam cells formation

► Statins inhibit macrophage cholesterol biosynthesis and oxidation. ► Phytosterol (β-sitosterol) and antioxidant (punicalagin), improve these effects. ► Pomegranate juice contains both compounds, and shows similar effects.