کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
596049 1454034 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Preparation of solid lipid particles by membrane emulsification—Influence of process parameters
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی شیمی کلوئیدی و سطحی
پیش نمایش صفحه اول مقاله
Preparation of solid lipid particles by membrane emulsification—Influence of process parameters
چکیده انگلیسی

The present study investigates the preparation of solid lipid particles using the membrane emulsification process. The lipid phase is pressed, at a temperature above the melting point of the lipid, through the membrane pores allowing the formation of small droplets. The aqueous phase circulates inside the membrane device, and sweeps away the droplets forming at the pore outlets. The influence of the lipid phase (Compritol 888 and Gelucire 44/14), and the pores size of SPG membranes on the solid lipid particles size and on the lipid flux is investigated. The membrane emulsification process allows obtaining solid lipid particles with a mean size between 50 and 750 nm, and a lipid phase flux between 0.008 and 0.84 m3/h m2. The high fluxes obtained with the 0.1 μm pore size SPG membrane suggest that scaling-up could be possible for industrial applications. However, further work is needed to reduce fouling obtained during the preparation of solid lipid particles with the small membrane pore size (0.2 and 0.4 μm).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 338, Issues 1–3, 15 April 2009, Pages 114–118
نویسندگان
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