کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6013781 | 1185922 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Functional MRI and neuropsychological evidence for language plasticity before and after surgery in one patient with left temporal lobe epilepsy
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کلمات کلیدی
Neuropsychological assessment - ارزیابی عصب شناختیEpilepsy - بیماری صرعfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیLanguage - زبانReorganization - سازماندهی مجددSurgery - عمل جراحیphonology - فونولوژی، واج شناسیSemantics - معناشناسی یا معنیشناسیTemporal - موقتیPlasticity - پلاستیک
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
This study explores the language reorganization before and after surgery in a 55-year-old right-handed female patient presenting with left temporal refractory epilepsy. Two aspects of language were explored, phonological and semantic, by using neuropsychological assessments and fMRI protocols. To assess the possible reorganization of language, fMRI results for B.L. were compared with results obtained in a group of healthy control subjects (results not presented in detail). According to our results and compared with healthy subjects, B.L. shows reorganization of temporal regions only. The reorganization had various patterns according to the task. Before surgery, neuropsychological testing in B.L. revealed impairment in phonological abilities and fMRI suggested right temporal involvement (interhemisphere reorganization) during the phonological task; semantic abilities were unaltered and fMRI showed bilateral activation of temporal regions during the semantic task. After surgery, the phonological deficit disappeared and fMRI showed left perilesional location of temporal activation (intrahemispheric reorganization); semantic abilities remain preserved and temporal activation remained located bilaterally but predominantly to the right during the semantic task. Our results suggest that cerebral reorganization of language depends on the language operation tested. Moreover, the results underline the importance of differential assessment of language operations and show functional reorganization after beneficial surgery in an older patient.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 23, Issue 1, January 2012, Pages 81-86
Journal: Epilepsy & Behavior - Volume 23, Issue 1, January 2012, Pages 81-86
نویسندگان
M. Perrone-Bertolotti, R. Zoubrinetzky, G. Yvert, J.F. Le Bas, M. Baciu,