Brain damage and IQ in unilateral Sturge-Weber syndrome: Support for a “fresh start” hypothesis

► The relationship of extent of severe hypometabolism (on fluorodeoxyglucose positron emission tomography) to IQ outcome is U-shaped. ► Small extent of severe hypometabolism is associated with good cognitive function. ► Large extent may also be associated with preserved (although not normal) IQ outcome. ► When the extent of severe hypometabolism is < 15%, a good outcome is probable. ► As the area of severe hypometabolism increases > 60%, IQ increases.