کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6017638 1580171 2014 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Environmental enrichment restores CA1 hippocampal LTP and reduces severity of seizures in epileptic mice
چکیده انگلیسی
We have analyzed the effects of environmental enrichment (EE) in a seizure-prone mouse model in which the genetic disruption of the presynaptic protein Bassoon leads to structural and functional alterations in the hippocampus and causes early spontaneous seizures mimicking human neurodevelopmental disorders. One-month EE starting at P21 reduced seizure severity, preserved long-term potentiation (LTP) and paired-pulse synaptic responses in the hippocampal CA1 neuronal population and prevented the reduction of spine density and dendrite branching of pyramidal neurons. These data demonstrate that EE exerts its therapeutic effect by normalizing multiple aspects of hippocampal function and provide experimental support for its use in the optimization of existent treatments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 261, November 2014, Pages 320-327
نویسندگان
, , , , , , , , , , ,