Fingolimod reduces cerebral lymphocyte infiltration in experimental models of rodent intracerebral hemorrhage

► We applied Fingolimod, an S1P agonist, in two murine experimental stroke models. ► Fingolimod reduced short-term brain edema and neurological deficits after ICH. ► T-lymphocytes and cerebral ICAM-1, IFN-γ, and IL-17 were reduced by Fingolimod. ► Fingolimod reduced long-term behavioral deficits and brain tissue damage.