Endoplasmic reticulum stress contributes to prediabetic peripheral neuropathy

► Endoplasmic reticulum stress contributes to prediabetic neuropathy. ► Trimethylamine oxide abrogates sciatic nerve ER stress in Zucker fatty rats. ► Trimethylamine oxide alleviates prediabetic neuropathy in Zucker fatty rats. ► Salubrinal improves glucose tolerance in high-fat diet fed mice. ► Salubrinal alleviates peripheral nerve dysfunction in high-fat diet fed mice.