Grafting of fetal brainstem 5-HT neurons into the sublesional spinal cord of paraplegic rats restores coordinated hindlimb locomotion

► Transplants of fetal 5-HT neurons restore coordinated locomotion in spinal rats. ► 5-HT2A and 5-HT7 receptors contribute to transplant-mediated recovery of locomotion. ► 5-HT2A receptors control motoneuron and locomotor CPG activities in transplanted rats. ► 5-HT7 receptors control CPG neurons but not motoneurons in transplanted rats.