Neurobehavioral alterations in HIV-1 transgenic rats: Evidence for dopaminergic dysfunction

► HIV-1 Tg rats show altered PPI, novelty response, habituation and Coc sensitization. ► Deficits were prior to any noted neurological symptoms or clinical signs of wasting. ► Alterations in the DA system are implicated in the non-infectious HIV-1 Tg rat.