Traumatic brain injury and trichloroethylene exposure interact and produce functional, histological, and mitochondrial deficits

► TCE and TBI interact synergistically and lead to neurological deficits. ► The interaction of TCE and TBI leads to functional and histological pathology. ► The mitochondrion plays a pivotal role in the interaction of TCE and TBI. ► Pathology can result even when the individual insults are sub-pathological.