Anti-Nogo-A and training: Can one plus one equal three?

► The adult central nervous system has a limited capacity for repair following spinal cord injury. ► Recovery is affected by: age; the size/location of the lesion; and remaining circuit activity. ► Two potential treatments are neutralising growth inhibition and rehabilitative training. ► Independently, both approaches lead to functional recovery and anatomical reorganisation. ► In combination, the outcome is less clear. The mechanisms for this are currently being unravelled.