A reassessment of a classic neuroprotective combination therapy for spinal cord injured rats: LPS/pregnenolone/indomethacin

► Partial replication of a classic SCI experiment in rats using forceps compression injury model. ► A novel triple combination therapy is neuroprotective and promotes partial recovery of function. ► Data show comparisons of historical Tarlov open field scoring with modern BBB scoring. ► Combination of drugs that regulates pro-­and anti-­inflammatory signaling may have therapeutic benefit.