Dysregulated neuronal-microglial cross-talk during aging, stress and inflammation

▶ The interaction of neurons and microglia is essential in maintaining CNS homeostasis. ▶ Aging and stress lead to heightened neuroinflammation and increased microglial reactivity. ▶ Neuronal control of microglial activation is disrupted by aging, stress and inflammation. ▶ Loss of neuronal-microglial communication has deleterious consequences for brain and behavior.