کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6019487 | 1186561 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Edaravone - اداروونهamyotrophic lateral sclerosis (ALS) - اسکلروز جانبی جانبی آمیوتروفیک (ALS)Immunohistochemistry - ایمونوهیستوشیمیAggregation - تجمعTreatment - درمانanterior horn cell - سلول شاخ قدامیSuperoxide dismutase - سوکسوکس دیسموتازMotor function - عملکرد موتورMouse model - مدل موشFree-radical scavenger - مهاجم آزاد رادیکال
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice](/preview/png/6019487.png)
چکیده انگلیسی
Edaravone is a free-radical scavenger, an agent being widely used for cerebral ischemia in Japan. To evaluate its efficacy for possible treatment of amyotrophic lateral sclerosis (ALS), we performed a randomized blind trial in ALS model mice. After identification of the clinical onset in each female G93A mutant SOD1 transgenic mouse, we intraperitoneally administered multiple doses of edaravone to the mice and observed their motor symptoms. We also counted the number of lumbar motoneurons, determined the 3-nitrotyrosine/tyrosine ratio, and evaluated the abnormal SOD1 aggregation in the spinal cord at the 10th day after the edaravone injection. Edaravone significantly slowed the motor decline of the transgenic mice. The remaining motoneurons were significantly preserved in the higher-dose edaravone-administered group, and the 3-nitrotyrosine/tyrosine ratios were reduced dose-dependently. Intriguingly, the area of abnormal SOD1 deposition in the spinal cord was significantly decreased in the higher-dose edaravone-administered group. Our results indicate that edaravone was effective to slow symptom progression and motor neuron degeneration in the ALS model mice. These favorable actions might be attributable to the yet unidentified mechanism responsible for reducing the deposition of mutant SOD1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 213, Issue 2, October 2008, Pages 448-455
Journal: Experimental Neurology - Volume 213, Issue 2, October 2008, Pages 448-455
نویسندگان
Hidefumi Ito, Reika Wate, Jianhua Zhang, Shizuo Ohnishi, Satoshi Kaneko, Hisashi Ito, Satoshi Nakano, Hirofumi Kusaka,