کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6019517 | 1186582 | 2008 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
In vivo gene delivery for development of mammalian models for Parkinson's disease
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
PSIPrPMFBAAVPDGF-βMPTPPael-RLRRK2UCH-L1DATCsCl6-HydroxydopaminePINK-16-OHDAPTEN-induced kinase 1RCAqPCRUbiquitin carboxy-terminal hydrolase L1gene transfer - انتقال ژنN-methyl-4-phenyl-1,2,3,6-tetrahydropyridine - N-methyl-4-phenyl-1،2،3،6-tetrahydropyridineAdenovirus - آدنوویروسAlpha-synuclein - آلفا سینوئولینDopamine transporter - انتقال دهنده دوپامینmedial forebrain bundle - بسته نرم افزاری پروبیالParkinson's disease - بیماری پارکینسونsubstantia nigra - توده سیاهDopamine - دوپامینplatelet derived growth factor - فاکتور رشد حاصل از پلاکتDisease modeling - مدل سازی بیماریWild type. - نوع وحشی.transducing units - واحدهای انتقالquantitative polymerase chain reaction - واکنش زنجیره ای پلیمراز کمیAdeno-associated virus - ویروس Adeno مرتبط استLentivirus - ویروس آهستهگستر، لنتی ویروسPrion protein - پروتئین پریونcesium chloride - کلرید سزیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: In vivo gene delivery for development of mammalian models for Parkinson's disease In vivo gene delivery for development of mammalian models for Parkinson's disease](/preview/png/6019517.png)
چکیده انگلیسی
During the last decade, identification of the genes involved in familial forms of Parkinson's disease (PD) has advanced our understanding of the mechanisms underlying the development of different aspects of PD. However the available animal models still remain as the main limiting factor for the development of neuroprotective therapies that can halt the progression of the disease, through which we wish to provide a better quality of life for the PD patients. Here, we review the recently developed animal models based on overexpression of PD-associated genes using recombinant viral vectors. Recombinant adeno-associated viral vectors, in particular, have been very useful in targeting the nigral dopamine neurons both in the rodent and the primate brain. In order to provide insights into the establishment of these models in the laboratory, we will not only give an overview of the results from these studies but also cover practical issues related to the production and handling of the viral vectors, which are critical for the successful application of this approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Neurology - Volume 209, Issue 1, January 2008, Pages 89-100
Journal: Experimental Neurology - Volume 209, Issue 1, January 2008, Pages 89-100
نویسندگان
Ayse Ulusoy, Tomas Bjorklund, Stephan Hermening, Deniz Kirik,