Increased subcortical neural activity among HIVÂ + individuals during a lexical retrieval task

During phonemic fluency performance, HIV + patients recruit subcortical structures to a greater degree than HIV − controls despite similar task performances suggesting that fMRI may be sensitive to neurocompromise before overt cognitive declines can be detected. Among HIV + individuals, reduced activity in the frontal-subcortical structures was associated with lower CD4 + count.