Mitochondrial abnormalities in temporal lobe of autistic brain

► We identify mitochondria respiratory chain protein defects and oxidative stress in autism brain temporal lobe. ► We found altered mitochondrial dynamics in autism temporal lobe. ► We report the neuronal accumulation of compromised mitochondria in temporal lobe of autism brain. ► We detected no mtDNA mutations in ASD brain. ► Mechanisms regulating mitochondrial gene transcription are intact in autism brain temporal lobe.