Altered Purkinje cell miRNA expression and SCA1 pathogenesis

► The expression of several miRNAs is altered early in the pathogenesis of SCA1. ► miR-150 expression is increased in the Purkinje cells of SCA1 transgenic mice. ► miR-150 targets Rgs8 and Vegfa in cultured neuronal cells, two mRNAs down-regulated in SCA1. ► Reducing mutant ataxin-1 levels increases miR-150 and Vegfa.