کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6022399 1580675 2013 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
Dopaminergic imaging of nonmotor manifestations in a rat model of Parkinson's disease by fMRI
چکیده انگلیسی

Nonmotor manifestations determine the life quality of patients with Parkinson's disease (PD). Identification of the nonmotor symptoms in PD as definite changes will represent a milestone in its diagnosis. Outcome measures that characterize nonmotor manifestations with specificity for dopaminergic deficiency are essential to that goal. Pain is a prevalent sensory disturbance in PD patients. The prevalence was reported to be up to 83%. Nociceptive stimuli under normal conditions elicit decreases in cerebral blood volume (CBV) in the striatum via dopaminergic neurotransmission. This nociception-induced CBV response is potentially to be defined as a characteristic of the pain symptom of PD. To validate this concept, steady-state CBV-weighted functional magnetic resonance imaging with iron oxide nanoparticles was employed to measure CBV changes in parkinsonian rats. Tyrosine hydroxylase immunohistology was used to identify the dopaminergic integrity to corroborate the imaging findings. Additional experiments that tested pain responses in parkinsonism were also carried out. The results revealed that the lesioned striatum exhibited a weakened CBV decrease in response to the nociceptive stimulus. This weakened CBV response occurred mainly in areas with dopaminergic denervation. A strong correspondence was observed between the distributions of the nociception-induced CBV responses and dopaminergic innervation. The persisting CBV signals in the striatum were abolished by the D2/D3 antagonist eticlopride. The findings of these behavioral, neuroimaging, immunohistological, and pharmacological experiments demonstrate that pain in a rat model of PD can be characterized by nociception induced striatal CBV signal changes with specificity for dopaminergic dysfunction.

► In Parkinson's disease (PD), nociception induces specific hemodynamics in the striatum. ► The hemodynamic changes are detected by cerebral blood volume (CBV)-weighted fMRI. ► In the intact striatum, nociception induces widespread and strong CBV decreases. ► But the lesioned striatum exhibits weakened and restricted CBV decreases. ► The findings support dopaminergic imaging of nonmotor manifestations in PD by fMRI.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 49, January 2013, Pages 99-106
نویسندگان
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