Metabolic stress response implicated in diabetic retinopathy: The role of calpain, and the therapeutic impact of calpain inhibitor

► High fat and hyperglycemia-induced ganglion cells death via calpain activation. ► Hyperglycemia-induced RGC-deaths was mediated by oxidative stress in vitro. ► Inhibition of calpain and oxidative stress signals had a neuroprotective effect.